Protein / target

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

PTENP60484
UniProt: P60484
9
Research papers

Protein at a glance

Research activity

Emerging research

9 papers · latest 2023

Derived from structured UniProt, Open Targets and literature data on this page.

Research activity

9 papers · to 2023

Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.

Most cited

Comprehensive molecular characterization of clear cell renal cell carcinoma.2,739 cites

Nature · 2013

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.1,095 cites

Kimura I · Nature communications · 2013

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.994 cites

Mellinghoff IK · The New England journal of medicine · 2005

Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial.304 cites

Schmid P · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020

Regulating tumor suppressor genes: post-translational modifications.295 cites

Chen L · Signal transduction and targeted therapy · 2020

Recent

Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis.

Chaudagar K · Clinical cancer research : an official journal of the American Association for Cancer Research · 2023

MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.

Doha ZO · Nature communications · 2023

N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.

Deng J · Cell death & disease · 2023

Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial.

Turner NC · The Lancet. Oncology · 2020

Regulating tumor suppressor genes: post-translational modifications.

Chen L · Signal transduction and targeted therapy · 2020

Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial.

Schmid P · Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.

Kimura I · Nature communications · 2013

Comprehensive molecular characterization of clear cell renal cell carcinoma.

Nature · 2013

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

Mellinghoff IK · The New England journal of medicine · 2005

Europe PMC papers linked directly to this protein.