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PTGER2

Gene

prostaglandin E receptor 2

HGNCHGNC:9594EnsemblENSG00000125384NCBI Gene5732
Locus: gene with protein productLocation: 14q22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Prostaglandin E2 receptor EP2 subtypeP43116

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Member of “Receptors, Prostaglandin” · 1 related family paper (context, not papers about this gene)

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCOX-2 · EP2
View full nomenclature history (4)
Alias symbolsCOX-2, EP2
Previous namesprostaglandin E receptor 2 (subtype EP2), 53kD, prostaglandin E receptor 2 (subtype EP2), 53kDa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Ocular Hypertension
Glaucoma
Glaucoma, Open-Angle
Neurodegenerative Diseases
Response to antihypertensive drug

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Prostaglandin receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-07-01.
Open TargetsGene–disease associations from the Open Targets Platform.