PTPN11

Gene

protein tyrosine phosphatase non-receptor type 11

HGNCHGNC:9644 EnsemblENSG00000179295 NCBI Gene5781

Locus: gene with protein productLocation: 12q24.13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tyrosine-protein phosphatase non-receptor type 11Q06124

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNS1 · BPTP3 · SH-PTP2 · SHP-2 · PTP2C · SHP2

View full nomenclature history (9)

Previous symbolsNS1

Alias symbolsBPTP3, SH-PTP2, SHP-2, PTP2C, SHP2

Previous namesNoonan syndrome 1, protein tyrosine phosphatase, non-receptor type 11

Alias namesSH2 domain-containing protein tyrosine phosphatase 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Noonan syndrome

Noonan syndrome with multiple lentigines

Leukemia, Myeloid, Acute

Neoplasms

RASopathy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SH2 domain containingProtein tyrosine phosphatases non-receptor type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.