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RAPGEF2

Gene

Rap guanine nucleotide exchange factor 2

HGNCHGNC:16854EnsemblENSG00000109756NCBI Gene9693
Locus: gene with protein productLocation: 4q32.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPDZGEF1 · PDZ-GEF1 · RA-GEF · DKFZP586O1422 · KIAA0313
View full nomenclature history (8)
Previous symbolsPDZGEF1
Alias symbolsPDZ-GEF1, RA-GEF, DKFZP586O1422, KIAA0313
Previous namesPDZ domain containing guanine nucleotide exchange factor (GEF) 1, Rap guanine nucleotide exchange factor (GEF) 2
Alias namesRap GEP

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Lymphoid
Drug Hypersensitivity
Nutritional deficiency disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PDZ domain containingMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.