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RB1

Gene

RB transcriptional corepressor 1

HGNCHGNC:9884EnsemblENSG00000139687NCBI Gene5925
Locus: gene with protein productLocation: 13q14.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asOSRC · RB · PPP1R130
View full nomenclature history (7)
Previous symbolsOSRC
Alias symbolsRB, PPP1R130
Previous namesosteosarcoma, retinoblastoma 1
Alias namesprepro-retinoblastoma-associated protein, protein phosphatase 1, regulatory subunit 130

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Retinoblastoma
Urinary Bladder Neoplasms
Urinary bladder carcinoma
Small Cell Lung Carcinoma
Carcinoma, Hepatocellular
Adenocarcinoma of Lung
Osteosarcoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Receptor ligands

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.