RBCK1

Gene

RANBP2-type and C3HC4-type zinc finger containing 1

HGNCHGNC:15864 EnsemblENSG00000125826 NCBI Gene10616

Locus: gene with protein productLocation: 20p13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC20orf18 · RBCK2 · XAP4 · RNF54 · ZRANB4 · UBCE7IP3 · HOIL1

View full nomenclature history (10)

Previous symbolsC20orf18

Alias symbolsRBCK2, XAP4, RNF54, ZRANB4, UBCE7IP3, HOIL1

Previous nameschromosome 20 open reading frame 18, RanBP-type and C3HC4-type zinc finger containing 1

Alias namesheme-oxidized IRP2 ubiquitin ligase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn

Neurodegenerative Diseases

Autoimmune disorder of central nervous system

Glycogen storage disease due to glycogen branching enzyme deficiency

Alzheimer's Disease

Alcohol drinking

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsZinc fingers RANBP2-typeLinear ubiquitin chain assembly complexRBR E3 ubiquitin ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.