REXO4

Gene

RNA exonuclease 4

HGNCHGNC:12820 EnsemblENSG00000148300 NCBI Gene57109

Locus: gene with protein productLocation: 9q34.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asXPMC2H · hPMC2

View full nomenclature history (6)

Previous symbolsXPMC2H

Alias symbolshPMC2

Previous namesREX4 homolog, 3'-5' exonuclease, Xenopus prevents mitotic catatrophe 2 homolog, XPMC2 prevents mitotic catastrophe 2 homolog (Xenopus laevis), REX4, RNA exonuclease 4 homolog (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Liver Neoplasms

Carcinoma, Hepatocellular

COVID-19

Lymphoma, Large B-Cell, Diffuse

Thymoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Exonucleases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-10-10.

Open TargetsGene–disease associations from the Open Targets Platform.