RIGI

Gene

RNA sensor RIG-I

HGNCHGNC:19102 EnsemblENSG00000107201 NCBI Gene23586

Locus: gene with protein productLocation: 9p21.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Antiviral innate immune response receptor RIG-IO95786

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDDX58 · RIG-I · FLJ13599 · DKFZp434J1111 · RIG-1 · RIG1

View full nomenclature history (11)

Previous symbolsDDX58

Alias symbolsRIG-I, FLJ13599, DKFZp434J1111, RIG-1, RIG1

Previous namesDEAD (Asp-Glu-Ala-Asp) box polypeptide 58, DExD/H-box helicase 58

Alias namesretinoic acid inducible gene I, RNA helicase RIG-I, Antiviral innate immune response receptor RIG-I

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Psoriasis

COVID-19

Psoriasis vulgaris

Diabetes Mellitus, Type 2

Macular Degeneration

Genetic Diseases, Inborn

Carcinoma, Hepatocellular

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DEAD-box helicasesCaspase recruitment domain containingRIG-I RNA sensor family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.