ROS1

Gene

ROS proto-oncogene 1, receptor tyrosine kinase

HGNCHGNC:10261 EnsemblENSG00000047936 NCBI Gene6098

Locus: gene with protein productLocation: 6q22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proto-oncogene tyrosine-protein kinase ROSP08922

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMCF3 · ROS · c-ros-1

View full nomenclature history (6)

Alias symbolsMCF3, ROS, c-ros-1

Previous namesv-ros avian UR2 sarcoma virus oncogene homolog 1, v-ros UR2 sarcoma virus oncogene homolog 1 (avian), c-ros oncogene 1 , receptor tyrosine kinase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Neoplasms

Adenocarcinoma of Lung

Lung carcinoma

Melanoma

Squamous cell lung carcinoma

Cutaneous melanoma

Spitz nevus

Melanocytic neoplasm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Fibronectin type III domain containingROS proto-oncogene 1, receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.