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RUNX2

Gene

RUNX family transcription factor 2

HGNCHGNC:10472EnsemblENSG00000124813NCBI Gene860
Locus: gene with protein productLocation: 6p21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCCD · CBFA1 · CCD1 · AML3 · PEBP2A1 · PEBP2aA1
View full nomenclature history (8)
Previous symbolsCCD, CBFA1, CCD1
Alias symbolsAML3, PEBP2A1, PEBP2aA1
Previous namesrunt-related transcription factor 2, runt related transcription factor 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Genetic Diseases, Inborn
Craniosynostoses
Osteoarthritis
Osteoarthritis, Hip

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Runt-related transcription factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.