RXRA

Gene

retinoid X receptor alpha

HGNCHGNC:10477 EnsemblENSG00000186350 NCBI Gene6256

Locus: gene with protein productLocation: 9q34.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Retinoic acid receptor RXR-alphaP19793

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Member of “Retinoid X Receptors” · 1 related family paper (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNR2B1 · RXRalpha · RXR-alpha

View full nomenclature history (5)

Alias symbolsNR2B1, RXRalpha, RXR-alpha

Previous namesretinoid X receptor, alpha

Alias namesnuclear receptor subfamily 2 group B member 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Psoriasis

Lymphoma, T-Cell, Cutaneous

Psoriasis vulgaris

Urinary Bladder Neoplasms

Sarcoma, Kaposi

Neoplasms

Carcinoma, Non-Small-Cell Lung

Urinary bladder carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genesRetinoid X receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.