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S1PR2

Gene

sphingosine-1-phosphate receptor 2

HGNCHGNC:3169EnsemblENSG00000267534NCBI Gene9294
Locus: gene with protein productLocation: 19p13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sphingosine 1-phosphate receptor 2O95136

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asEDG5 · DFNB68 · Gpcr13 · H218 · AGR16
View full nomenclature history (7)
Previous symbolsEDG5, DFNB68
Alias symbolsGpcr13, H218, AGR16
Previous namesendothelial differentiation, sphingolipid G-protein-coupled receptor, 5, deafness, autosomal recessive 68

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Sclerosis
Hearing loss, autosomal recessive
Deafness
Non-syndromic genetic deafness
Nonsyndromic genetic hearing loss
Hypertension

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sphingosine 1-phosphate receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.