Back to discover

S1PR3

Gene

sphingosine-1-phosphate receptor 3

HGNCHGNC:3167EnsemblENSG00000213694NCBI Gene1903
Locus: gene with protein productLocation: 9q22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sphingosine 1-phosphate receptor 3Q99500

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asEDG3 · C9orf47 · C9orf108 · EDG-3 · FLJ37523 · bA791O21.3
View full nomenclature history (10)
Previous symbolsEDG3, C9orf47, C9orf108
Alias symbolsEDG-3, FLJ37523, bA791O21.3
Previous namesendothelial differentiation, sphingolipid G-protein-coupled receptor, 3, chromosome 9 open reading frame 47, chromosome 9 open reading frame 108
Alias namessphingosine-1-phosphate receptor 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting
Gastrointestinal disease
Lymphadenitis
Thrombocytopenia 4
Ovarian neoplasm

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sphingosine 1-phosphate receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.