SCN11A

Gene

sodium voltage-gated channel alpha subunit 11

HGNCHGNC:10583 EnsemblENSG00000168356 NCBI Gene11280

Locus: gene with protein productLocation: 3p22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium channel protein type 11 subunit alphaQ9UI33

Protein · therapeutic target

Clinically validated target · 59 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCN12A · Nav1.9 · NaN · SNS-2

View full nomenclature history (8)

Previous symbolsSCN12A

Alias symbolsNav1.9, NaN, SNS-2

Previous namessodium channel, voltage-gated, type XI, alpha polypeptide, sodium channel, voltage-gated, type XII, alpha, sodium channel, voltage-gated, type XI, alpha subunit, sodium channel, voltage gated, type XI alpha subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Familial episodic pain syndrome with predominantly lower limb involvement

Hereditary sensory and autonomic neuropathy type 7

Familial episodic pain syndrome

Major depressive disorder

Epilepsy

Bipolar Disorder

Lennox-Gastaut syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sodium voltage-gated channel alpha subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.