SCN1A

Gene

sodium voltage-gated channel alpha subunit 1

HGNCHGNC:10585 EnsemblENSG00000144285 NCBI Gene6323

Locus: gene with protein productLocation: 2q24.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium channel protein type 1 subunit alphaP35498

Protein · therapeutic target

Clinically validated target · 59 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCN1 · FEB3 · Nav1.1 · GEFSP2 · HBSCI · NAC1 · SMEI

View full nomenclature history (10)

Previous symbolsSCN1, FEB3

Alias symbolsNav1.1, GEFSP2, HBSCI, NAC1, SMEI

Previous namesfebrile convulsions 3, sodium channel, voltage-gated, type I, alpha subunit, sodium channel, voltage gated, type I alpha subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Epilepsies, Myoclonic

Generalized epilepsy with febrile seizures plus, type 2

Generalized epilepsy with febrile seizures-plus

Epilepsy

Migraine, familial hemiplegic, 3

Genetic developmental and epileptic encephalopathy

Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy

Lennox-Gastaut syndrome

Febrile seizures, familial, 3a

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sodium voltage-gated channel alpha subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.