SCN2A

Gene

sodium voltage-gated channel alpha subunit 2

HGNCHGNC:10588 EnsemblENSG00000136531 NCBI Gene6326

Locus: gene with protein productLocation: 2q24.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium channel protein type 2 subunit alphaQ99250

Protein · therapeutic target

Clinically validated target · 59 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCN2A1 · SCN2A2 · Nav1.2 · HBSCII · HBSCI

View full nomenclature history (9)

Previous symbolsSCN2A1, SCN2A2

Alias symbolsNav1.2, HBSCII, HBSCI

Previous namessodium channel, voltage-gated, type II, alpha 2 polypeptide, sodium channel, voltage-gated, type II, alpha 1 polypeptide, sodium channel, voltage-gated, type II, alpha subunit, sodium channel, voltage gated, type II alpha subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Developmental and epileptic encephalopathy, 11

Seizures, benign familial infantile, 3

Episodic ataxia, type 9

Bipolar Disorder

Epilepsy

Benign familial infantile epilepsy

Complex neurodevelopmental disorder

Epilepsies, Partial

Infantile spasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sodium voltage-gated channel alpha subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-04-24.

Open TargetsGene–disease associations from the Open Targets Platform.