SCN8A

Gene

sodium voltage-gated channel alpha subunit 8

HGNCHGNC:10596 EnsemblENSG00000196876 NCBI Gene6334

Locus: gene with protein productLocation: 12q13.13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium channel protein type 8 subunit alphaQ9UQD0

Protein · therapeutic target

Clinically validated target · 59 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMED · Nav1.6 · NaCh6 · PN4 · CerIII · CIAT

View full nomenclature history (9)

Previous symbolsMED

Alias symbolsNav1.6, NaCh6, PN4, CerIII, CIAT

Previous namessodium channel, voltage gated, type VIII, alpha polypeptide, sodium channel, voltage gated, type VIII, alpha subunit, sodium channel, voltage gated, type VIII alpha subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Developmental and epileptic encephalopathy, 13

Seizures, benign familial infantile, 5

Cognitive impairment with or without cerebellar ataxia

Epilepsy

early-infantile DEE

Undetermined early-onset epileptic encephalopathy

Epilepsies, Partial

Complex neurodevelopmental disorder

Benign familial infantile epilepsy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sodium voltage-gated channel alpha subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.