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SCN9A

Gene

sodium voltage-gated channel alpha subunit 9

HGNCHGNC:10597EnsemblENSG00000169432NCBI Gene6335
Locus: gene with protein productLocation: 2q24.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium channel protein type 9 subunit alphaQ15858

Protein · therapeutic target

Clinically validated target · 59 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNav1.7 · PN1 · NE-NA · NENA · ETHA
View full nomenclature history (8)
Alias symbolsNav1.7, PN1, NE-NA, NENA, ETHA
Previous namessodium channel, voltage-gated, type IX, alpha polypeptide, sodium channel, voltage-gated, type IX, alpha subunit, sodium channel, voltage gated, type IX alpha subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Primary erythermalgia
Paroxysmal extreme pain disorder
Channelopathy-associated congenital insensitivity to pain, autosomal recessive
Hereditary sensory and autonomic neuropathy type 2
Epilepsy
Channelopathy-associated congenital insensitivity to pain
Bipolar Disorder
Hereditary sensory and autonomic neuropathy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sodium voltage-gated channel alpha subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.