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Disease

Hereditary sensory and autonomic neuropathy type 2

Late-stage therapeutic development
Also known as HSAN2, Hereditary Sensory and Autonomic Neuropathy Type II, autosomal recessive sensory radicular neuropathy, hereditary sensory and autonomic neuropathy type II+4 more

HSAN2, Hereditary Sensory and Autonomic Neuropathy Type II, autosomal recessive sensory radicular neuropathy, hereditary sensory and autonomic neuropathy type II, neurogenic acroosteolysis, Giaccai type acroosteolysis, hereditary sensory neuropathy type 2, hereditary sensory radicular neuropathy, recessive form.

24
Clinical trials
6
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q1 2028.
Upcoming Milestones
Clinical Milestones8View
Results expected 4
Recently completed 1
Other updates 3
Activity timeline8

Clinical trials

18 sponsors · 2 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Phase III Trial of Neoadjuvant Durvalumab (NSC 778709) Plus Chemotherapy Versus Chemotherapy Alone for Adults With MammaPrint High 2 Risk (MP2) Hormone Receptor (HR) Positive / Human Epidermal Growth Factor Receptor (HER2) Negative Stage II-III Breast Cancer

Phase 3 · Recruiting · National Cancer Institute (NCI)

Effectiveness and Cost-effectiveness of Ozone Treatment in Patients With Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (OzoParQT)

Phase 2/3 · Recruiting · Bernardino Clavo, MD, PhD

A Study on the Effect of GLP-1 Receptor Agonist (GLP-1RA) Intervention on Cardiac Autonomic Neuropathy in Patients With Type 2 Diabetes Mellitus

Phase 4 · Recruiting · The First Affiliated Hospital with Nanjing Medical University

Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy : a Phase 3 Randomized Multicentric Open-label Study.

Phase 3 · Recruiting · Institut Cancerologie de l'Ouest

Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment

Phase 4 · Recruiting · Massachusetts General Hospital

A Randomized Control Trial to Investigate the Effect of Growth Hormone on the Euploid Rate of Blastocyst in Patients With Advanced Maternal Age

Phase 3 · Recruiting · ShangHai Ji Ai Genetics & IVF Institute
Recruiting

Phase III Trial of Neoadjuvant Durvalumab (NSC 778709) Plus Chemotherapy Versus Chemotherapy Alone for Adults With MammaPrint High 2 Risk (MP2) Hormone Receptor (HR) Positive / Human Epidermal Growth Factor Receptor (HER2) Negative Stage II-III Breast Cancer

Phase 3 · Recruiting · National Cancer Institute (NCI)

Effectiveness and Cost-effectiveness of Ozone Treatment in Patients With Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (OzoParQT)

Phase 2/3 · Recruiting · Bernardino Clavo, MD, PhD

A Study on the Effect of GLP-1 Receptor Agonist (GLP-1RA) Intervention on Cardiac Autonomic Neuropathy in Patients With Type 2 Diabetes Mellitus

Phase 4 · Recruiting · The First Affiliated Hospital with Nanjing Medical University

Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy : a Phase 3 Randomized Multicentric Open-label Study.

Phase 3 · Recruiting · Institut Cancerologie de l'Ouest

Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment

Phase 4 · Recruiting · Massachusetts General Hospital

A Randomized Control Trial to Investigate the Effect of Growth Hormone on the Euploid Rate of Blastocyst in Patients With Advanced Maternal Age

Phase 3 · Recruiting · ShangHai Ji Ai Genetics & IVF Institute
Recently completed

Efficacy of Thymoquinone as an Adjuvant Treatment With Pregabalin for the Treatment of Neuropathy in Diabetic Patients: A Randomized Clinical Trial of 65 mg of Thymoquinone and 75 mg Pregabalin Daily for Two Months

Phase 4 · Completed · Hawler Medical University

The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Patients With Cancer Treated With Oxaliplatin-fluorouracil Chemotherapy Protocols

Phase 3 · Completed · Aya Mohamed Sadek Elsaid

Effects of Botulinum Toxin A on Selective Motor Control in Cerebral Palsy: A Simultaneous Assessment of Upper and Lower Extremities

Phase 4 · Completed · Gaziosmanpasa Research and Education Hospital

Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy-TINSAL -T1DN

Phase 2/3 · Completed · University of Michigan

An Adaptive, Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy of Engensis in Participants With Painful Diabetic Peripheral Neuropathy

Phase 3 · Completed · Helixmith Co., Ltd.

Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety and Tolerability of AD04 (Ondansetron) in Adults With Alcohol Use Disorder (AUD) and Selected Polymorphisms in the Serotonin Transporter and Receptor Genes

Phase 3 · Completed · Adial Pharmaceuticals

Associated genes

6 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

WNK10.77RETREG10.74SCN9A0.66KIF1A0.62SPTLC10.46P3H40.04

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Sodium channel protein type 9 subunit alphavia SCN9A0.66

Reference

Authoritative identity, definition & identifiers.

Synonyms

HSAN2, Hereditary Sensory and Autonomic Neuropathy Type II, autosomal recessive sensory radicular neuropathy, hereditary sensory and autonomic neuropathy type II, neurogenic acroosteolysis, Giaccai type acroosteolysis, hereditary sensory neuropathy type 2, hereditary sensory radicular neuropathy, recessive form

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.