SERPINC1

Gene

serpin family C member 1

HGNCHGNC:775 EnsemblENSG00000117601 NCBI Gene462

Locus: gene with protein productLocation: 1q25.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Antithrombin-IIIP01008

Protein · therapeutic target

Clinically validated target · 10 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAT3 · ATIII · MGC22579

View full nomenclature history (9)

Previous symbolsAT3

Alias symbolsATIII, MGC22579

Previous namesserine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1

Alias namesantithrombin III, signal peptide antithrombin part 1, coding sequence signal peptide antithrombin part 1, antithrombin (aa 375-432)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hereditary antithrombin deficiency

Venous Thromboembolism

Venous Thrombosis

Blood Coagulation Disorders

Pulmonary Embolism

Atrial Fibrillation

Myocardial Infarction

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serpin peptidase inhibitors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.