SERPIND1

Gene

serpin family D member 1

HGNCHGNC:4838 EnsemblENSG00000099937 NCBI Gene3053

Locus: gene with protein productLocation: 22q11.21

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHCF2 · HC-II · HLS2 · HC2 · D22S673

View full nomenclature history (9)

Previous symbolsHCF2

Alias symbolsHC-II, HLS2, HC2, D22S673

Previous namesserine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1

Alias namesheparin cofactor II, heparin cofactor 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Thrombosis

Ovarian carcinoma

Ovarian Neoplasms

hereditary thrombophilia due to congenital protein C deficiency

Thrombophilia due to thrombin defect

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serpin peptidase inhibitors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.