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SERPINE1

Gene

serpin family E member 1

HGNCHGNC:8583EnsemblENSG00000106366NCBI Gene5054
Locus: gene with protein productLocation: 7q22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPLANH1 · PAI1 · PAI
View full nomenclature history (5)
Previous symbolsPLANH1, PAI1
Alias symbolsPAI
Previous namesserine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Alias namesplasminogen activator inhibitor, type I

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Venous Thromboembolism
Coronary Artery Disease
Ischemic Stroke
Thrombosis
Metabolic Syndrome
Glioblastoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serpin peptidase inhibitors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.