SERPING1

Gene

serpin family G member 1

HGNCHGNC:1228 EnsemblENSG00000149131 NCBI Gene710

Locus: gene with protein productLocation: 11q12.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Plasma protease C1 inhibitorP05155

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC1NH · C1IN · C1-INH · HAE1 · HAE2 · C1INH

View full nomenclature history (11)

Previous symbolsC1NH

Alias symbolsC1IN, C1-INH, HAE1, HAE2, C1INH

Previous namesserine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary), serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

Alias namesplasma protease C1 inhibitor, angioedema, hereditary, C1-inhibitor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Angioedemas, Hereditary

Angioedema

Genetic Diseases, Inborn

Asthma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serpin peptidase inhibitorsComplement system regulators and receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.