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SETX

Gene

senataxin

HGNCHGNC:445EnsemblENSG00000107290NCBI Gene23064
Locus: gene with protein productLocation: 9q34.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asALS4 · SCAR1 · KIAA0625 · AOA2 · Sen1 · STEX
View full nomenclature history (8)
Previous symbolsALS4, SCAR1
Alias symbolsKIAA0625, AOA2, Sen1, STEX
Previous namesamyotrophic lateral sclerosis 4, spinocerebellar ataxia, recessive, non-Friedreich type 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Neurodegenerative Diseases
Cerebellar Ataxia
Amyotrophic Lateral Sclerosis
Frontotemporal Dementia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

UPF1 like RNA helicasesSSU processome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.