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SF3B3

Gene

splicing factor 3b subunit 3

HGNCHGNC:10770EnsemblENSG00000189091NCBI Gene23450
Locus: gene with protein productLocation: 16q22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSAP130 · SF3b130 · RSE1 · KIAA0017
View full nomenclature history (7)
Alias symbolsSAP130, SF3b130, RSE1, KIAA0017
Previous namessplicing factor 3b, subunit 3, 130kD, splicing factor 3b, subunit 3, 130kDa
Alias namesspliceosome-associated protein 130

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Dengue
Familial prostate cancer
Prostatic Neoplasms
Joint Diseases
Zika Virus Infection

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SF3b complexSmall nucleolar RNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.