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SH2B3

Gene

SH2B adaptor protein 3

HGNCHGNC:29605EnsemblENSG00000111252NCBI Gene10019
Locus: gene with protein productLocation: 12q24.12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLNK · IDDM20
View full nomenclature history (3)
Alias symbolsLNK, IDDM20
Alias nameslymphocyte adaptor protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Celiac Disease
Diabetes Mellitus, Type 1
Hypertension
Coronary Artery Disease
Hypothyroidism
Myocardial Infarction
Ischemic Stroke
Myeloproliferative disorder
Arthritis, Rheumatoid

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingSH2 domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.