SIGIRR

Gene

single Ig and TIR domain containing

HGNCHGNC:30575 EnsemblENSG00000185187 NCBI Gene59307

Locus: gene with protein productLocation: 11p15.5

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTIR8 · IL-1R8

View full nomenclature history (5)

Alias symbolsTIR8, IL-1R8

Previous namessingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Alias namessingle immunoglobulin domain IL1R1 related, Toll/interleukin-1 receptor 8

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Neoplasms

Infections

Arthritis, Rheumatoid

Lupus Erythematosus, Systemic

Enterocolitis, Necrotizing

Breast Neoplasms

Carcinoma, Renal Cell

Metabolic Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Immunoglobulin like domain containingTIR domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-11-01.

Open TargetsGene–disease associations from the Open Targets Platform.