SIRPA

Gene

signal regulatory protein alpha

HGNCHGNC:9662 EnsemblENSG00000198053 NCBI Gene140885

Locus: gene with protein productLocation: 20p13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPTPNS1 · SHPS1 · SIRP · MYD-1 · BIT · P84 · SHPS-1 · SIRPalpha · CD172a · SIRPalpha2 · MFR · SIRP-ALPHA-1

View full nomenclature history (14)

Previous symbolsPTPNS1

Alias symbolsSHPS1, SIRP, MYD-1, BIT, P84, SHPS-1, SIRPalpha, CD172a, SIRPalpha2, MFR, SIRP-ALPHA-1

Previous namesprotein tyrosine phosphatase, non-receptor type substrate 1, signal-regulatory protein alpha

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2

Neurodegenerative Diseases

Leukemia, Myeloid, Acute

Colorectal adenocarcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesV-set domain containingC1-set domain containingSignal regulatory proteinsIg-like cell adhesion molecule family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.