SIRT3

Gene

sirtuin 3

HGNCHGNC:14931 EnsemblENSG00000142082 NCBI Gene23410

Locus: gene with protein productLocation: 11p15.5

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

NAD-dependent protein deacetylase sirtuin-3, mitochondrialQ9NTG7

Protein · therapeutic target

Member of “Sirtuins” · 7 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSIR2L3

View full nomenclature history (3)

Alias symbolsSIR2L3

Previous namessirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3, sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Intracranial Aneurysm

Female reproductive system disorder

Coronary Artery Disease

Neoplasms

Acute Kidney Injury

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sirtuins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-02-06.

Open TargetsGene–disease associations from the Open Targets Platform.