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SMAD6

Gene

SMAD family member 6

HGNCHGNC:6772EnsemblENSG00000137834NCBI Gene4091
Locus: gene with protein productLocation: 15q22.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMADH7 · MADH6 · HsT17432
View full nomenclature history (5)
Previous symbolsMADH7, MADH6
Alias symbolsHsT17432
Previous namesMAD, mothers against decapentaplegic homolog 6 (Drosophila), SMAD, mothers against DPP homolog 6 (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Aortic Valve Stenosis
Glaucoma, Open-Angle

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SMAD family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.