SMS

Gene

spermine synthase

HGNCHGNC:11123 EnsemblENSG00000102172 NCBI Gene6611

Locus: gene with protein productLocation: Xp22.11

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Spermine synthaseP52788

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSRS · SPMSY · SpS · MRSR

View full nomenclature history (5)

Previous symbolsSRS

Alias symbolsSPMSY, SpS, MRSR

Previous namesSnyder-Robinson X-linked mental retardation syndrome

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn

Autoimmune disorder of central nervous system

Neurodegenerative Diseases

Developmental Disabilities

Colorectal Neoplasms

Pancreatic Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

7BS non-methyltransferases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-11-08.

Open TargetsGene–disease associations from the Open Targets Platform.