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SOHLH1

Gene

spermatogenesis and oogenesis specific basic helix-loop-helix 1

HGNCHGNC:27845EnsemblENSG00000165643NCBI Gene402381
Locus: gene with protein productLocation: 9q34.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC9orf157 · NOHLH · TEB2 · bA100C15.3 · bHLHe80 · SPATA27
View full nomenclature history (8)
Previous symbolsC9orf157
Alias symbolsNOHLH, TEB2, bA100C15.3, bHLHe80, SPATA27
Previous nameschromosome 9 open reading frame 157
Alias namesspermatogenesis associated 27

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

46,XX gonadal dysgenesis
Spermatogenic failure
Primary Ovarian Insufficiency
Neurodegenerative Diseases
Genetic non-acquired premature ovarian failure
Carcinoma, Ductal, Breast
Central Nervous System Neoplasms
Glioma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Basic helix-loop-helix proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.