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SQSTM1

Gene

sequestosome 1

HGNCHGNC:11280EnsemblENSG00000161011NCBI Gene8878
Locus: gene with protein productLocation: 5q35.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sequestosome-1Q13501

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPDB3 · OSIL · p62 · p60 · p62B · A170
View full nomenclature history (9)
Previous symbolsPDB3, OSIL
Alias symbolsp62, p60, p62B, A170
Previous namesPaget disease of bone 3, oxidative stress induced like
Alias namesautophagy receptor p62

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Amyotrophic Lateral Sclerosis
bone Paget's disease
Osteosarcoma
Neoplasms
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers ZZ-type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.