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SYNE4

Gene

spectrin repeat containing nuclear envelope family member 4

HGNCHGNC:26703EnsemblENSG00000181392NCBI Gene163183
Locus: gene with protein productLocation: 19q13.12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC19orf46 · DFNB76 · FLJ36445 · Nesprin-4 · Nesp4
View full nomenclature history (7)
Previous symbolsC19orf46, DFNB76
Alias symbolsFLJ36445, Nesprin-4, Nesp4
Previous nameschromosome 19 open reading frame 46, deafness, autosomal recessive 76

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hearing loss, autosomal recessive
Deafness
Nonsyndromic genetic hearing loss
Non-syndromic genetic deafness

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Spectrin repeat containing nuclear envelope familyKASH domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.