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SYNGAP1

Gene

synaptic Ras GTPase activating protein 1

HGNCHGNC:11497EnsemblENSG00000197283NCBI Gene8831
Locus: gene with protein productLocation: 6p21.32

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSYNGAP · RASA5 · KIAA1938
View full nomenclature history (4)
Alias symbolsSYNGAP, RASA5, KIAA1938
Previous namessynaptic Ras GTPase activating protein 1 homolog (rat)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Complex neurodevelopmental disorder
Genetic Diseases, Inborn
Neurodevelopmental Disorders
Developmental Disabilities

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

C2 and RasGAP domain containingMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-04-24.
Open TargetsGene–disease associations from the Open Targets Platform.