TBX21

Gene

T-box transcription factor 21

HGNCHGNC:11599 EnsemblENSG00000073861 NCBI Gene30009

Locus: gene with protein productLocation: 17q21.32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

T-box transcription factor TBX21Q9UL17

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTBLYM · T-bet

View full nomenclature history (4)

Alias symbolsTBLYM, T-bet

Previous namesT-box 21

Alias namesT-box transcription factor expressed in T cells

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypothyroidism

Thyroid Diseases

Neurodegenerative Diseases

Asthma

Childhood onset asthma

Lower respiratory tract disorder

Hashimoto's Disease

Autoimmune Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

T-box transcription factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-01-16.

Open TargetsGene–disease associations from the Open Targets Platform.