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Disease

Childhood onset asthma

Late-stage therapeutic development

Also known as asthma of childhood, childhood asthma, paediatric asthma, pediatric asthma.

24
Clinical trials
12
Associated genes
12
Related proteins
Current focus
Chitinase-3-like 1 biologyTherapeutic developmentToll-like 1 biologyInflammation & immunity

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 5 clinical trials expected to report results, the earliest in Q3 2027.
  • 3 industry developments reported.
Upcoming Milestones
Clinical Milestones13View all 13
Results expected 5
Recently completed 5
Other updates 3
+5 more in the activity timeline below
Industry & Market3View
Activity timeline16

Clinical trials

16 sponsors · 6 new · 5 completed in the last 12 months (net +5)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

The MODIFY Study: A Phase 3b/4 Randomized, Double-blind, Placebo-controlled, Multi-centre Study Evaluating the Impact of Early Intervention With Depemokimab on Exacerbation Rate, Clinical Remission, Lung Function Decline, and Safety in Adults and Adolescents With at Risk Type 2 Asthma, Conducted up to 156 Weeks

Phase 3 · Recruiting · GlaxoSmithKline

TAPER: A Prospective, Interventional, Multicentre, Single-Arm, Phase 3b Study to Evaluate the Step-Down of Maintenance Therapy in Patients With Severe Asthma Treated With Tezepelumab

Phase 3 · Recruiting · AstraZeneca

A Multinational, Investigator-initiated, Parallel Group, Randomised, Double-blind, Placebo-controlled Phase 3b Superiority Trial Assessing the Effect of Dupilumab on Inducing Clinical Remission Outcomes in At-risk Type-2 Inflammatory Asthma (HOTHOT)

Phase 3 · Recruiting · Université de Sherbrooke

A Randomized, Double-Blind, Placebo-Controlled Phase Ⅲ Clinical Study of Evaluating the Efficacy and Safety of CM326 in Subjects With Moderate to Severe Asthma

Phase 3 · Recruiting · CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.

Individualizing Treatment for Asthma in Primary Care (Full Study)

Phase 4 · Recruiting · DARTNet Institute

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma

Phase 3 · Recruiting · Generate Biomedicines
Recruiting

The MODIFY Study: A Phase 3b/4 Randomized, Double-blind, Placebo-controlled, Multi-centre Study Evaluating the Impact of Early Intervention With Depemokimab on Exacerbation Rate, Clinical Remission, Lung Function Decline, and Safety in Adults and Adolescents With at Risk Type 2 Asthma, Conducted up to 156 Weeks

Phase 3 · Recruiting · GlaxoSmithKline

TAPER: A Prospective, Interventional, Multicentre, Single-Arm, Phase 3b Study to Evaluate the Step-Down of Maintenance Therapy in Patients With Severe Asthma Treated With Tezepelumab

Phase 3 · Recruiting · AstraZeneca

A Multinational, Investigator-initiated, Parallel Group, Randomised, Double-blind, Placebo-controlled Phase 3b Superiority Trial Assessing the Effect of Dupilumab on Inducing Clinical Remission Outcomes in At-risk Type-2 Inflammatory Asthma (HOTHOT)

Phase 3 · Recruiting · Université de Sherbrooke

A Randomized, Double-Blind, Placebo-Controlled Phase Ⅲ Clinical Study of Evaluating the Efficacy and Safety of CM326 in Subjects With Moderate to Severe Asthma

Phase 3 · Recruiting · CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.

Individualizing Treatment for Asthma in Primary Care (Full Study)

Phase 4 · Recruiting · DARTNet Institute

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma

Phase 3 · Recruiting · Generate Biomedicines
Recently completed

Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol in Individuals With Cough Variant Asthma and Chronic Cough

Phase 4 · Completed · Dr. Diane Lougheed

The ALOHA Trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern

Phase 2/3 · Completed · University of Illinois at Chicago

STEP: A Prospective, Interventional, Multicenter, Single-Arm Phase 3b Study to Evaluate the Step-Down of Maintenance Therapy in Patients With Severe Eosinophilic Asthma Treated With Benralizumab

Phase 3 · Completed · AstraZeneca

A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma

Phase 3 · Completed · Bridgette Jones

REVErsing Airway Remodelling With Tezepelumab : a Protocol for a Double-blind Randomized Controlled Trial for Patients With Asthma

Phase 3 · Completed · University Hospital, Montpellier

A Pilot Interventional Study to Evaluate the Safety and Tolerability of Mirabegron and Montelukast in Patients With Liver Cirrhosis

Phase 4 · Completed · Kafrelsheikh University

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

FLG0.67IL4R0.51IL1RL10.50IL330.50TLR10.50IL130.49SUOX0.49OTULINL0.48TESPA10.48TSLP0.46NOD20.46IRAG10.45

Disease biology

12 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Interleukin-4 receptor subunit alphavia IL4R0.51Interleukin-1 receptor-like 1via IL1RL10.50Interleukin-33via IL330.50Toll-like receptor 1via TLR10.50Interleukin-13via IL130.49Nucleotide-binding oligomerization domain-containing protein 2via NOD20.46Protein kinase C theta typevia PRKCQ0.45Tumor necrosis factor ligand superfamily member 4via TNFSF40.43C-C motif chemokine 20via CCL200.40T-box transcription factor TBX21via TBX210.38Interleukin-4via IL40.18Chitinase-3-like protein 1via CHI3L10.17

Reference

Authoritative identity, definition & identifiers.

Synonyms

asthma of childhood, childhood asthma, paediatric asthma, pediatric asthma

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.