TIE1

Gene

tyrosine kinase with immunoglobulin like and EGF like domains 1

HGNCHGNC:11809 EnsemblENSG00000066056 NCBI Gene7075

Locus: gene with protein productLocation: 1p34.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTIE · JTK14

View full nomenclature history (4)

Previous symbolsTIE

Alias symbolsJTK14

Previous namestyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cardiovascular Diseases

Neoplasms

Uterine Cervical Neoplasms

Ovarian carcinoma

Ovarian Neoplasms

Carcinoma, Non-Small-Cell Lung

Nasopharyngeal Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Fibronectin type III domain containingImmunoglobulin like domain containingTyrosine kinase with immunoglobulin like and EGF like domains family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.