Back to discover

TJP2

Gene

tight junction protein 2

HGNCHGNC:11828EnsemblENSG00000119139NCBI Gene9414
Locus: gene with protein productLocation: 9q21.11

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDFNA51 · ZO-2 · X104 · ZO2
View full nomenclature history (7)
Previous symbolsDFNA51
Alias symbolsZO-2, X104, ZO2
Previous namesdeafness, autosomal dominant 51
Alias namesFriedreich ataxia region gene X104 (tight junction protein ZO-2), zona occludens 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Deafness
Refractive Errors
Genetic Diseases, Inborn
Myopia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Membrane associated guanylate kinasesPDZ domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.