TLE1

Gene

TLE family member 1, transcriptional corepressor

HGNCHGNC:11837 EnsemblENSG00000196781 NCBI Gene7088

Locus: gene with protein productLocation: 9q21.32

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asESG1 · GRG1 · ESG · TLE-1

View full nomenclature history (7)

Alias symbolsESG1, GRG1, ESG, TLE-1

Previous namestransducin-like enhancer of split 1 (E(sp1) homolog, Drosophila), transducin like enhancer of split 1

Alias namesenhancer of split groucho 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2

Diabetes Mellitus

Diabetic Retinopathy

Diabetic Neuropathies

Immune System Diseases

Graves' Disease

Tooth disorder

Alcohol drinking

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

WD repeat domain containingWnt enhanceosome complexTLE family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.