TLE2

Gene

TLE family member 2, transcriptional corepressor

HGNCHGNC:11838 EnsemblENSG00000065717 NCBI Gene7089

Locus: gene with protein productLocation: 19p13.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asESG2 · GRG2 · ESG · FLJ41188

View full nomenclature history (7)

Alias symbolsESG2, GRG2, ESG, FLJ41188

Previous namestransducin like enhancer of split 2, transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)

Alias namesenhancer of split groucho 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Esophageal Squamous Cell Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

WD repeat domain containingWnt enhanceosome complexTLE family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.