Back to discover

TMPRSS6

Gene

transmembrane serine protease 6

HGNCHGNC:16517EnsemblENSG00000187045NCBI Gene164656
Locus: gene with protein productLocation: 22q12.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFLJ30744 · MT2
View full nomenclature history (4)
Alias symbolsFLJ30744, MT2
Previous namestransmembrane protease, serine 6
Alias namesmatriptase-2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Anemia
Iron Metabolism Disorders
Neurodegenerative Diseases
Hematologic Diseases
Carbohydrate Metabolism, Inborn Errors

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Type II transmembrane serine proteases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.