TNFRSF11A

Gene

TNF receptor superfamily member 11a

HGNCHGNC:11908 EnsemblENSG00000141655 NCBI Gene8792

Locus: gene with protein productLocation: 18q21.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tumor necrosis factor receptor superfamily member 11AQ9Y6Q6

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPDB2 · LOH18CR1 · RANK · CD265 · FEO · ODFR · TRANCE-R

View full nomenclature history (15)

Previous symbolsPDB2, LOH18CR1

Alias symbolsRANK, CD265, FEO, ODFR, TRANCE-R

Previous namesPaget disease of bone 2, tumor necrosis factor receptor superfamily, member 11a, activator of NFKB, loss of heterozygosity, 18, chromosomal region 1, tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Alias namesosteoclast differentiation factor receptor, receptor activator of nuclear factor kappa B, familial expansile osteolysis, TRANCE receptor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesTumor necrosis factor receptor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.