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TRHDE

Gene

thyrotropin releasing hormone degrading enzyme

HGNCHGNC:30748EnsemblENSG00000072657NCBI Gene29953
Locus: gene with protein productLocation: 12q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPGPEP2 · TRH-DE · PAP-II
View full nomenclature history (7)
Alias symbolsPGPEP2, TRH-DE, PAP-II
Previous namesthyrotropin-releasing hormone degrading enzyme
Alias namespyroglutamyl-peptidase II, pyroglutamyl aminopeptidase II, TRH-specific aminopeptidase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Smoking initiation
Risk-taking behaviour
Kidney Diseases
Obesity disorder
Attention Deficit Disorder with Hyperactivity
Poisoning

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

M1 metallopeptidases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.