TUBB3

Gene

tubulin beta 3 class III

HGNCHGNC:20772 EnsemblENSG00000258947 NCBI Gene10381

Locus: gene with protein productLocation: 16q24.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tubulin beta-3 chainQ13509

Protein · therapeutic target

Clinically validated target · 25 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFEOM3 · beta-4 · CFEOM3 · CFEOM3A

View full nomenclature history (7)

Previous symbolsFEOM3

Alias symbolsbeta-4, CFEOM3, CFEOM3A

Previous namestubulin, beta 3, fibrosis of extraocular muscles, congenital, 3

Alias namesclass III beta-tubulin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement

Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation

Complex cortical dysplasia with other brain malformations 1

Congenital fibrosis of the extraocular muscles

Breast Neoplasms

Neoplasms

Prostatic Neoplasms

Carcinoma, Non-Small-Cell Lung

Hodgkin's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Tubulin beta family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.