TXNRD1

Gene

thioredoxin reductase 1

HGNCHGNC:12437 EnsemblENSG00000198431 NCBI Gene7296

Locus: gene with protein productLocation: 12q23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Thioredoxin reductase 1, cytoplasmicQ16881

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Member of “selenoproteins” · 1 related family paper (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTXNR · GRIM-12 · Trxr1 · TXNR1

View full nomenclature history (5)

Alias symbolsTXNR, GRIM-12, Trxr1, TXNR1

Alias namesselenoprotein TXNRD1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Acute promyelocytic leukemia

Neoplasms

Brain Neoplasms

Leukemia, Myeloid, Acute

Carcinoma, Non-Small-Cell Lung

Schizophrenia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SelenoproteinsGlutaredoxin domain containingFlavoproteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-07-21.

Open TargetsGene–disease associations from the Open Targets Platform.