U2AF1

Gene

U2 small nuclear RNA auxiliary factor 1

HGNCHGNC:12453 EnsemblENSG00000160201 NCBI Gene7307

Locus: gene with protein productLocation: 21q22.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asU2AFBP · U2AF35 · RNU2AF1 · RN

View full nomenclature history (6)

Previous symbolsU2AFBP

Alias symbolsU2AF35, RNU2AF1, RN

Previous namesU2(RNU2) small nuclear RNA auxiliary factor binding protein, U2(RNU2) small nuclear RNA auxiliary factor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Myeloid, Acute

Adenocarcinoma of Lung

Neurodegenerative Diseases

Myelodysplastic syndrome

Carcinoma, Non-Small-Cell Lung

Chronic myelomonocytic leukemia

Lung carcinoma

chronic myelogenous leukemia, BCR-ABL1 positive

Myelofibrosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers CCCH-typeRNA binding motif containingSpliceosomal A complexSpliceosomal E complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.