XRCC4

Gene

X-ray repair cross complementing 4

HGNCHGNC:12831 EnsemblENSG00000152422 NCBI Gene7518

Locus: gene with protein productLocation: 5q14.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known ashXRCC4

View full nomenclature history (4)

Alias symbolshXRCC4

Previous namesX-ray repair complementing defective repair in Chinese hamster cells 4

Alias namesX-ray repair, complementing defective, repair in Chinese hamster, DNA repair protein XRCC4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

HIV Infections

Microcephalic primordial dwarfism

Non-acquired isolated growth hormone deficiency

Alopecia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-11-06.

Open TargetsGene–disease associations from the Open Targets Platform.