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XRCC6

Gene

X-ray repair cross complementing 6

HGNCHGNC:4055EnsemblENSG00000196419NCBI Gene2547
Locus: gene with protein productLocation: 22q13.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asG22P1 · D22S731 · KU70 · ML8 · D22S671
View full nomenclature history (9)
Previous symbolsG22P1
Alias symbolsD22S731, KU70, ML8, D22S671
Previous namesthyroid autoantigen 70kD (Ku antigen), thyroid autoantigen 70kDa (Ku antigen), X-ray repair complementing defective repair in Chinese hamster cells 6
Alias namesKu autoantigen, 70kDa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

HIV Infections
Neurodegenerative Diseases
Intelligence
Carcinoma, Hepatocellular
Neuroblastoma
Neoplasms
Huntington's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

HelicasesDNA-(apurinic or apyrimidinic site) lyases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.