Protein / target
CD70 antigen
Protein at a glance
Biological role
Tumor necrosis factor receptor binding
Strongest disease association
Severe Combined Immunodeficiency
Therapeutic position
Clinically advancing target
Research activity
Emerging research
Derived from structured UniProt, Open Targets and literature data on this page.
Protein profile
Canonical identity and biological annotation from UniProt.
Function overview
Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells.
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Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864)
Subcellular location
Domains and Gene Ontology detail (15)Hide
Domains & features
Gene Ontology
- Cextracellular exosome
- Cplasma membrane
- Freceptor ligand activity
- Ftumor necrosis factor receptor binding
- Padaptive immune memory response involving T cells and B cells
- PB cell mediated immunity
- PB cell proliferation
- PCD27 signaling pathway
- Pextrinsic apoptotic signaling pathway
- Ppositive regulation of T cell proliferation
- PT cell activation
- PT cell mediated immunity
Biological roles
What this protein does, drawn together from its UniProt function, Gene Ontology terms and Reactome pathways.
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Immune signalling
- ·Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which…
- ·adaptive immune memory response involving T cells and B cells
- ·B cell mediated immunity
- ·B cell proliferation
Concepts derived from UniProt GO Reactome — each badge above shows which sources supported that role.
Translational evidence
Why this target matters therapeutically, strongest evidence first. Disease associations are gene-level (via the gene that encodes this protein) and open into the full confidence synthesis; the development universe, tractability and safety annotations are target-level, from Open Targets.
Strongest disease associations · via encoding gene CD70
Gene-level evidence surfaced through the gene CD70that encodes this protein — not a direct protein–disease relationship. Ranked by Forefront's causal-directness weighting, so genetically- and clinically-evidenced diseases lead over ones that merely share the literature.
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The evidence agreement range shows how closely the independent evidence families agree — it is not a statistical confidence interval, and nothing here is fitted to outcome data. Derived from Open Targets evidence types under Forefront weighting; the per-type scores above show the calculation.
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Drug development
4 compounds recorded · 4 in clinical development
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Open Targets known-drugs universe. Drug name and highest clinical stage only — the disease relationship is NOT read from this slice (it carries trial-context noise); approved indications come from the canonical graph above.
Tractability
Antibodies — Strong
Protein degraders — Emerging
Other modalities — Strong
View underlying tractability evidence (7)Hide
Raw Open Targets tractability assessment buckets, by modality.
Research activity
Papers linked directly to this protein. This is the protein's own literature — descriptor-derived papers are kept separate below.
Most cited
Recent
Europe PMC papers linked directly to this protein.